The Endocannabinoid System: A beginners Guide to Supplementing with Cannabis


The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website. These statements have not been evaluated by the food and drug administration (FDA). Cannabis and cannabis products are not intended to diagnose, treat, cure or prevent any disease.

Do not operate a vehicle or machinery under the influence of this drug. For use only by adults twenty-one years of age and older. Keep out of the reach of children.

Part two of our Blog Series on the Endocannabinoid System.

From Modern Science to Ancient Wisdom.

By Margo Sperry & Heather George, DSOM

Altering the human experience and, ultimately, the Endocannabinoid system by using cannabis is documented in some of the earliest Chinese and Hindu texts. The history of cannabis as both an intoxicant and medicine weaved throughout human history. The prohibition of marijuana has resulted in a shroud of mystery that is only now beginning to clear. Both studies and anecdotal evidence show that doctors, to varying degrees depending on location, continue to be limited in education, knowledge, and capacity to prescribe: including recommending variety (ideally based on the products chemical profile rather than its strain name), dosage, and methods of ingestion for the use of cannabis. 

At Portland’s dispensary Urban Farmacy, it is a regular occurrence for people to come into the store because their doctor suggested they try cannabis. However, these people have no further information from their doctors. It is primarily the dispensaries that are on the front lines of educating all types of cannabis users on everything from suggesting methods of ingestion to dosage. Largely, cannabis users are left to experiment independently to discover what works for them. With this in mind, let this be a beginner’s guide to help you navigate embarking on the journey of supplementing with cannabis.

Using cannabis is largely an experimental experience. Each person’s Endocannabinoid system is unique, therefore each person is going to need a unique cannabinoid and terpene profile to create the optimized personal experience. Additionally, each cannabis variety, even each plant, and each cannabis product will have its’ own unique cannabinoid and terpene profile. Wow, you might be thinking that in this world of infinite possibility, where do I start? Here are the basics of how we guide people to get started with cannabis.

  • Know what desired experience you are looking for:
    • Do you like the euphoric and psychoactive experience induced by THC?
    • Do you prefer to avoid the head high associated with THC?
    • Do you have anxiety?
    • Do you need to be high functioning?
    • Do you want to relax?
    • Are you treating a serious acute or chronic health condition? If so, what are is your desired outcome from using cannabis? Are you seeking symptom management or other properties reported by some people associated with cannabis?
  • Select your dispensary wisely. Only a very select few dispensaries will be able to answer your questions. At Urban Farmacy we are passionate about cannabis science and education. You will always find an experienced and knowledgeable person to answer your questions. 
  • Be prepared to experiment and try different cultivars (aka strains) and methods of ingestion. Know which methods of ingestion sound most appealing or fitting for you.
  • Start with a low dose – you can always increase your dose, but you cannot decrease it once you have consumed it. 
  • If you are interested in experiencing THC, but feel nervous. A CBD rich product that also contains THC is a good way to get started. This way you can experience the effects of THC while the CBD will help moderate the head high associated with cannabis. Many people can experience desirable and even euphoric effects of THC with as little as 1-2 mg of THC. Other people will need or desire a much higher dose of THC.   
  • When trying a new product: take your first dose of cannabis in the evening. This way if you experience any undesirable effects you will sleep it off.
  • Keeping a journal or some simple notes about which strains and products yield desirable effects for you will help guide your experimentation. Since each person’s body changes, note what time of day it was when you used each product.

There are many methods for supplementing with cannabis: smoking and vaporizing cannabis flowers, smoking and vaporizing cannabis extracts and concentrates, consuming edibles and pills, sublingual tinctures, inhalers, and topical salves. Each method of ingestion has a different onset time, duration, and effect. Additionally, there are different routes each method takes through the body. See the list below:

Smoking and Vaporizing: 

Onset: Immediate

Duration of Experience: 1-4 hours

How is the cannabis working inside my body: When a person smokes cannabis the cannabinoids and terpenes are immediately absorbed into the blood, which flows directly to the brain where the most abundant quantity of CB1 receptors reside.


Onset: 15m-1.5 hours

Duration of experience: 3-6 hours

How is the cannabis working inside my body: Cannabis edibles get absorbed through your digestive tract, including your liver. When you consume THC via an edible, your liver will convert it to 11-Hydroxy-THC, an active metabolite that will cross the blood brain barrier and bind to CB1 receptors inducing a long-lasting high. Most edibles take longer to onset, and also last longer. This will vary depending on the type of edible and your own body.

Sublingual Application:

Onset: Immediate – 20 minutes

Duration of Experience: 2-4 hours

How is the cannabis working inside my body: When placing cannabis sublingual preparations under the tongue or between the gums and the cheek, it is absorbed via the sublingual mucosa and moves directly to the blood, and then to the brain where the most abundant quantity of CB1 receptors reside.

Educating yourself about cannabis and the endocannabinoid system gives you the power to craft the experiences you wish to create for yourself. Learning what products are right for any individual at any given time is where cannabis science and education are evolving. More information is available on the cannabis education pages to help you understand cannabinoids and terpenes. We will also discuss cannabis varieties in more depth in an upcoming blog. 

Whatever your reasons for using cannabis, working with dispensaries and healthcare professionals who are committed to helping you understand the science behind (and beyond) this herb will ensure that you have the optimum experience. Urban Farmacy and our affiliates, like Dr. George, are here for you in this regard.


Most physicians In training not prepared to prescribe marijuana

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